{"product_id":"mots-c","title":"MOTS-c 10mg Pen","description":"\u003ch3\u003e\u003cspan class=\"\"\u003eUnderstanding MOTS-c 10mg:\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eThis product is available as a single use or reusable pen system, which uses refill cartridges for precise and convenient delivery.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eProduct Strength:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e\u003cspan\u003e \u003c\/span\u003e10mg per 2ml cartridge\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eStorage:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e\u003cspan\u003e \u003c\/span\u003eKeep at room temperature between 20–25 °C to maintain potency and stability.\u003c\/span\u003e\u003c\/p\u003e\n\u003chr\u003e\n\u003ch3\u003e\u003cspan class=\"\"\u003eWhat It Is\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eMOTS-c is a synthetic 16-amino acid peptide and a mitochondrial-derived peptide (MDP). It is encoded within the mitochondrial genome (specifically the 12S rRNA region), distinguishing it from nuclear-encoded peptides. As a member of the mitochondrial-derived peptide family, which includes Humanin and SHLP1-6, MOTS-c functions as a retrograde signaling molecule that communicates mitochondrial status to the nucleus to regulate cellular metabolism and stress responses.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eThe discovery of MOTS-c in 2015 by researchers at the University of Southern California represented a paradigm shift in understanding mitochondrial function. Prior to this, mitochondria were primarily viewed as cellular powerhouses; the identification of MOTS-c revealed that mitochondria actively secrete regulatory peptides that influence systemic metabolism. This discovery positioned MOTS-c as a potential therapeutic target for metabolic disorders, aging, and age-related diseases.\u003c\/span\u003e\u003c\/p\u003e\n\u003chr\u003e\n\u003ch3\u003e\u003cspan class=\"\"\u003eMechanism of Action\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eMOTS-c functions as a hormone-like peptide that regulates metabolic homeostasis through activation of the AICAR (5-aminoimidazole-4-carboxamide ribonucleotide) pathway. Unlike direct AMPK activators, MOTS-c binds to an as-yet-unidentified intracellular receptor, leading to AICAR accumulation, which subsequently activates AMP-activated protein kinase (AMPK) — the cell's master energy sensor.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eBy activating AMPK, MOTS-c triggers a cascade of metabolic effects:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eIncreased glucose uptake\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e\u003cspan\u003e \u003c\/span\u003ein skeletal muscle through GLUT4 translocation\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eEnhanced fatty acid oxidation\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e, promoting the utilization of lipids for energy\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eImproved mitochondrial biogenesis\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e\u003cspan\u003e \u003c\/span\u003eand efficiency\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eModulation of insulin sensitivity\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e, improving glycemic control\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eIn addition to its metabolic actions, MOTS-c has been shown to influence the cellular stress response by upregulating antioxidant defense mechanisms, reducing oxidative damage, and promoting cellular resilience. This dual action — improving metabolic function while simultaneously enhancing cellular protection — distinguishes MOTS-c from many other metabolic modulators.\u003c\/span\u003e\u003c\/p\u003e\n\u003chr\u003e\n\u003ch3\u003e\u003cspan class=\"\"\u003eKey Research Applications \u0026amp; Uses\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003ePrimary Research Applications:\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eMetabolic disorders and insulin resistance:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e\u003cspan\u003e \u003c\/span\u003eMOTS-c is being investigated for its ability to improve insulin sensitivity and glucose homeostasis in models of obesity, type 2 diabetes, and metabolic syndrome. Studies have demonstrated that MOTS-c administration significantly improves glucose tolerance and reduces fasting blood glucose levels in aged and diet-induced obese mice\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eAging and age-related decline:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e\u003cspan\u003e \u003c\/span\u003eAs circulating MOTS-c levels naturally decline with age, research is exploring exogenous administration as a potential intervention to counteract age-associated metabolic dysfunction, muscle weakness, and mitochondrial deterioration\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eEmerging \u0026amp; Investigational Uses:\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eExercise performance and recovery:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e\u003cspan\u003e \u003c\/span\u003eMOTS-c is being studied for its ability to mimic the metabolic benefits of exercise, enhancing endurance and facilitating recovery through improved fatty acid oxidation and reduced oxidative stress during physical exertion\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eNeuroprotection:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e\u003cspan\u003e \u003c\/span\u003ePreliminary research suggests MOTS-c may have neuroprotective properties, potentially offering benefits in neurodegenerative conditions through its effects on mitochondrial function and cellular stress resistance\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eBone health:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e\u003cspan\u003e \u003c\/span\u003eEmerging evidence indicates MOTS-c may play a role in osteoblast differentiation and bone formation, suggesting potential applications in osteoporosis and bone-related disorders\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eWeight management:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e\u003cspan\u003e \u003c\/span\u003eThe peptide's ability to enhance energy expenditure and fatty acid oxidation has led to exploration of its potential role in supporting healthy weight management\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch3\u003e\u003cspan class=\"\"\u003eAdministration \u0026amp; Dosage\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eMOTS-c is typically administered via subcutaneous injection, allowing for systemic distribution and consistent bioavailability.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eTiming:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e\u003cspan\u003e \u003c\/span\u003eFor metabolic benefits, dosing may be performed in the morning or before periods of anticipated metabolic demand. For exercise-related applications, administration approximately 30–60 minutes before physical activity is common\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eFrequency:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e\u003cspan\u003e \u003c\/span\u003eDosing protocols vary widely based on research objectives, typically ranging from once daily to several times weekly. Common research dosages range from 5mg to 10mg per administration, with cycle durations of 4–8 weeks commonly reported\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eOnset \u0026amp; Duration:\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eOnset:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e\u003cspan\u003e \u003c\/span\u003eEffects on metabolism and energy utilization typically begin within 30–60 minutes\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eDuration:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e\u003cspan\u003e \u003c\/span\u003eAcute metabolic effects may persist for 4–6 hours, with cumulative benefits observed with repeated dosing over time\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003chr\u003e\n\u003ch3\u003e\u003cspan class=\"\"\u003eContraindications \u0026amp; Precautions\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eMOTS-c is contraindicated or should be used with extreme caution in individuals with the following conditions:\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eUncontrolled metabolic disorders:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e\u003cspan\u003e \u003c\/span\u003eIndividuals with uncontrolled diabetes or severe hypoglycemic episodes should exercise caution, as MOTS-c may significantly alter glucose metabolism and insulin sensitivity\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003ePregnancy and lactation:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e\u003cspan\u003e \u003c\/span\u003eSafety during pregnancy and breastfeeding has not been established. Use is not recommended in these populations\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eHypersensitivity:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e\u003cspan\u003e \u003c\/span\u003eKnown allergy to MOTS-c or any component of the formulation\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eCancer or active malignancy:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e\u003cspan\u003e \u003c\/span\u003eDue to its effects on cellular metabolism and proliferation, use in individuals with active cancer or a history of malignancy should be approached with caution and only under strict medical supervision\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eAutoimmune conditions:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e\u003cspan\u003e \u003c\/span\u003eAs a bioactive peptide that influences immune and stress signaling pathways, use in autoimmune disorders should be carefully evaluated\u003c\/span\u003e\u003c\/p\u003e\n\u003chr\u003e\n\u003ch3\u003e\u003cspan class=\"\"\u003eAdverse Reactions \u0026amp; Side Effects\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eThe most common side effects associated with MOTS-c are generally mild and include:\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eInjection site reactions:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e\u003cspan\u003e \u003c\/span\u003eLocal redness, mild pain, or irritation at the injection site — the most frequently reported adverse effect\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eFlushing:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e\u003cspan\u003e \u003c\/span\u003eA feeling of warmth or redness of the skin, occasionally reported\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eDizziness or lightheadedness:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e\u003cspan\u003e \u003c\/span\u003eMay occur, particularly in individuals sensitive to changes in glucose metabolism\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eFatigue:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e\u003cspan\u003e \u003c\/span\u003eSome users report transient tiredness, particularly during the initial days of use\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eMild nausea:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e\u003cspan\u003e \u003c\/span\u003eLess common, typically mild and self-limiting\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eLong-Term or Rare Side Effects:\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eAlterations in glucose homeostasis:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e\u003cspan\u003e \u003c\/span\u003eIn susceptible individuals, changes in blood glucose regulation may occur; monitoring is advised for those with pre-existing glycemic issues\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eUnknown long-term effects:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan class=\"\"\u003e\u003cspan\u003e \u003c\/span\u003eAs a relatively recently discovered peptide, comprehensive long-term safety data in humans is limited\u003c\/span\u003e\u003c\/p\u003e\n\u003chr\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cstrong\u003e\u003cspan class=\"\"\u003eDisclaimer:\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"ds-markdown-paragraph\"\u003e\u003cspan class=\"\"\u003eThis information is for general knowledge and educational purposes only and does not constitute medical advice. Always consult with a qualified medical professional regarding any cosmetic or medical procedure.\u003c\/span\u003e\u003c\/p\u003e","brand":"All Peptides","offers":[{"title":"Default Title","offer_id":52832779763994,"sku":null,"price":1250.0,"currency_code":"ZAR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0987\/8926\/1594\/files\/image_6e79258b.jpg?v=1788896268","url":"https:\/\/allpeptides.co.za\/products\/mots-c","provider":"All Peptides","version":"1.0","type":"link"}